Effect of Diabetes on Osseointegration and Dental Implants
Effect of Diabetes on Osseointegration and Dental Implants
The tenacious hyperglycemia in diabetic people, hinder osteoblastic activity and modifies the response of parathyroid hormone that adjusts metabolism of Ca and P, decreases collagen synthesis during callus formation, induces apoptosis in lining cells of bone and increases osteoclastic activity due to untiring inflammatory response. It also stimulates deleterious effect on bone matrix and reduces growth and buildup of extracellular matrix. The subsequent result is reduced bone formation during healing.
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